Scientist (I, II) – Molecular and Cell Biology, Gene Therapy R&D
Our client is an early stage, gene therapy company who have developed a breakthrough RNA technology for safe gene insertion into the genome. It has the potential to disrupt the gene therapy/gene writing landscape. They have recently closed a significant series-A funding round and are now working to advance the therapeutic into the clinic. We have a great work culture and a brilliant set of employees.
We are seeking a scientist with a background in molecular and cell biology and genetic engineering. As part of a team, this individual will be responsible for conceiving, designing, and executing experiments to discover cellular factors and/or innovate biomolecules that can be combined with our core RNA gene therapy platform.
Projects will initially focus on permanent, targeted gene insertion into the genome for treating liver disease. Collaboration with other research teams could allow findings to be applied towards immuno-oncology and infectious disease therapeutics.
About the Role
The day-to-day responsibilities of this role will include:
QUALIFICATIONS (Except for those labeled as required, some but not all listed items are necessary)
- Design and execution of experiments using state-of-the-art methods, involving molecular biology, cell biology, and genetic engineering.
- Take-on, drive, and collaborate on team projects.
- Independently develop and drive projects.
- Communicate and present work at all levels of our organization and externally at conferences.
- Act as a mentor and role model, supporting the Addition Therapeutics culture.
- Participate and represent Addition in external and/or academic partnerships.
- Required: Ph.D. or post-doc in Molecular and Cellular Biology, Systems Biology, Biology, Genetics, Biochemistry, Bioengineering, Immunology, Cancer Biology, or related fields
- Required: Extensive, hands-on experience with molecular biology methods, cellular assays and mammalian cell culture
- FACS and immunofluorescence microscopy
- Vector and protein engineering through DNA sequence design, DNA synthesis, cloning, and/or assembly
- Lentiviral shRNA, CRISPR/Cas9, or CRISPR/Cas9ai genetic screens
- Cellular NGS assays plus bioinformatic analysis, e.g., ChiP-seq, ribosomal profiling
- Knowledge and experience with retroviral, transposon, or retroelement molecular biology
- Knowledge and experience with DNA repair, cell-cycle regulation, or nucleosome biology
- Self-motivated, disciplined, and passionate about hands-on work in the lab
- Excellent oral and written communication skills
- Thrives in a fast-moving, results-oriented startup environment
- Flexible, cooperative, can-do attitude
Our client is based in South San Francisco and offers a competitive salary package. As a growing company you'll have an impact on culture and dynamics with the opportunity to grow and develop. If this sounds like you, Apply today.